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This article is based upon work from COST Action CA21154 TRANSLACORE, supported by COST (European Cooperation in Science and Technology). Figure 1 is created with BioRender.

Analysis of institutional authors

Gebauer Hernández, FátimaAuthorJungfleisch, JenniferAuthor

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March 11, 2025
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Review
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RNA-binding proteins as therapeutic targets in cancer

Publicated to:Rna Biology. 22 (1): 1-8 - 2025-12-31 22(1), DOI: 10.1080/15476286.2025.2470511

Authors: Jungfleisch, J; Gebauer, F

Affiliations

Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Dr Aiguader 88, Barcelona 08003, Spain - Author
Univ Pompeu Fabra UPF, Barcelona, Spain - Author

Abstract

RNA-binding proteins (RBPs) have emerged as critical regulators of cancer progression, influencing virtually all hallmarks of cancer. Their ability to modulate gene expression patterns that promote or inhibit tumorigenesis has positioned RBPs as promising targets for novel anti-cancer therapies. This mini-review summarizes the current state of RBP-targeted cancer treatments, focusing on five examples, eIF4F, FTO, SF3B1, RBM39 and nucleolin. We highlight the diversity of current targeting approaches and discuss ongoing challenges including the complexity of RBP regulatory networks, potential off-target effects and the need for more specific targeting methods. By assessing the future potential of novel therapeutic avenues, we provide insights into the evolving landscape of cancer treatment and the critical role RBPs may play in next-generation therapeutics.

Keywords

AnimalsAntineoplastic agentsAntisense oligonucleotideAptamerAsoCancerCap-dependent translationCell-surfaceClinical-trialGene expression regulation, neoplasticHumansMessenger-rnaMolecular gluMolecular glueMolecular targeted therapyNeoplasmsRna-binding proteinsSham controSmall-molecule inhibitionSmiSplicing modulatorTherapeutic targetsTranslation initiation-factorU2 snrnp proteins

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Rna Biology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Molecular Biology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-19:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (JUNGFLEISCH, JENNIFER) and Last Author (Gebauer, Fatima).

the author responsible for correspondence tasks has been Gebauer, Fatima.