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Grant support

Work on germ cells in the B.P. laboratory has been supported by the Spanish Ministry of Science, Innovation and Universities; the Agencia Estatal de Investigacion (AEI, PID2021-123383NB-I00); the Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR, 2021 SGR 01222) and contributions from Clinica EUGIN. We would like to thank the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership and to the "Centro de Excelencia Severo Ochoa". We also acknowledge support of the CERCA Programme of the Generalitat de Catalunya.

Analysis of institutional authors

Mattimoe, TomAuthorPayer, BernhardAuthor

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December 11, 2023
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The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development

Publicated to:Biochemical Journal. 480 (8): 521-537 - 2023-04-01 480(8), DOI: 10.1042/bcj20220450

Authors: Mattimoe, T; Payer, B

Affiliations

Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Carrer Dr Aiguader 88, Barcelona 08003, Spain - Author
Univ Pompeu Fabra UPF, Barcelona, Spain - Author

Abstract

In female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and reactivation elicit global epigenetic regulation of expression from one X chromosome in a stage-specific manner, whilst the process of X-chromosome upregulation responds to this by fine-tuning transcription levels of the second X. The germline is unique in its function of transmitting both the genetic and epigenetic information from one generation to the next, and remodelling of the X chromosome is one of the key steps in setting the stage for successful development. Here, we provide an overview of the complex dynamics of X-chromosome dosage control during embryonic and germ cell development, and aim to decipher its potential role for normal germline competency.

Keywords

dosage compensationepigenetic reprogrammingx chromosomeCell-like cellsDna methylationEarly embryosFemale miceGene-expressionGerm cell developmentHistone h4Linked genesLong noncoding rnaMouse embryoUp-regulation

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biochemical Journal due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.12, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 5
  • Europe PMC: 6

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 10.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 14.95.
  • The number of mentions on the social network X (formerly Twitter): 22 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Mattimoe, Thomas) and Last Author (Payer, Bernhard).