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Analysis of institutional authors

Wright, RhgAuthorBeato, MAuthor

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May 2, 2023
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The ADP-ribose hydrolase NUDT5 is important for DNA repair

Publicated to: Cell Reports. 41 (12): 111866- - 2022-12-20 41(12), DOI: 10.1016/j.celrep.2022.111866

Authors:

Qi, HY; Wright, RHG; Beato, M; Price, BD
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Affiliations

Barcelona Inst Sci & Technol BIST, Ctr Regulac Genomica CRG, Barcelona 08003, Spain - Author
Harvard Med Sch, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02215 USA - Author
Univ Int Catalunya, Fac Med & Hlth Sci, Sant Cugat Del Valles 08195, Barcelona, Spain - Author
Univ Pompeu Fabra UPF, Barcelona, Spain - Author
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Abstract

DNA damage leads to rapid synthesis of poly(ADP-ribose) (pADPr), which is important for damage signaling and repair. pADPr chains are removed by poly(ADP-ribose) glycohydrolase (PARG), releasing free mono(ADP-ribose) (mADPr). Here, we show that the NUDIX hydrolase NUDT5, which can hydrolyze mADPr to ribose-5-phosphate and either AMP or ATP, is recruited to damage sites through interaction with PARG. NUDT5 does not regulate PARP or PARG activity. Instead, loss of NUDT5 reduces basal cellular ATP levels and exacerbates the decrease in cellular ATP that occurs during DNA repair. Further, loss of NUDT5 activity impairs RAD51 recruitment, attenuates the phosphorylation of key DNA-repair proteins, and reduces both H2A.Z exchange at damage sites and repair by homologous recombination. The ability of NUDT5 to hydrolyze mADPr, and/or regulate cellular ATP, may therefore be important for efficient DNA repair. Targeting NUDT5 to disrupt PAR/mADPr and energy metabolism may be an effective anti-cancer strategy.
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Keywords

atpchromatincp: cell biologycp: molecular biologydna repairenergy metabolismhomologous recombinationnudix hydrolasenudt5parpsActivationChromatin responseGene-regulationH2a.zMechanismMono(adp-ribose)ProteinsRemovalRibosylationStabilityStrand breaks

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cell Reports due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 32/191, thus managing to position itself as a Q1 (Primer Cuartil), in the category Cell Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-01:

  • WoS: 8
  • Europe PMC: 6
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 35.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 35 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions on the social network X (formerly Twitter): 6 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

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Awards linked to the item

This work was supported by funds from the Claudia Adams Barr Program in Cancer Research at the Dana-Farber Cancer Institute (B.D.P.). This will be B.D.P.'s last publication before moving on to better things.
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