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Analysis of institutional authors

Cantero-Recasens, GCorresponding AuthorMalhotra, VCorresponding Author

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April 11, 2022
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Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

Publicated to: Elife. 11 e73926- - 2022-02-08 11(), DOI: 10.7554/elife.73926

Authors:

Cantero-Recasens, G; Alonso-Maranon, J; Lobo-Jarne, T; Garrido, M; Iglesias, M; Espinosa, L; Malhotra, V; Ten Hagen, KG
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Affiliations

Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain - Author
CIBERONC Hosp Mar, Inst Mar Invest Med, Canc Res Program, Barcelona, Spain - Author
Hebron Res Inst VHIR, Renal Physiopathol Grp, Barcelona, Spain - Author
Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain - Author
Univ Autonoma Barcelona, Inst Mar Invest Med, Dept Pathol, CIBERONC, Barcelona, Spain - Author
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Abstract

Fifteen percent of colorectal cancer (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that CRC cells build a barrier to chemotherapeutics by increasing mucins' secretion. We show that low levels of KChIP3, a negative regulator of mucin secretion (Cantero-Recasens et al., 2018), is a risk factor for CRC patients' relapse in a subset of untreated tumours. Our results also reveal that cells depleted of KChIP3 are four times more resistant (measured as cell viability and DNA damage) to chemotherapeutics 5-fluorouracil + irinotecan (5-FU+iri.) compared to control cells, whereas KChIP3-overexpressing cells are 10 times more sensitive to killing by chemotherapeutics. A similar increase in tumour cell death is observed upon chemical inhibition of mucin secretion by the sodium/calcium exchanger (NCX) blockers (Mitrovic et al., 2013). Finally, sensitivity of CRC patient-derived organoids to 5-FU+iri. increases 40-fold upon mucin secretion inhibition. Reducing mucin secretion thus provides a means to control chemoresistance of mucinous CRC cells and other mucinous tumours.
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Keywords

5-fu+iri.cell biologychemoresistancechemotherapycolorectal cancerhumankchip35-fu+iriChemoresistanceChemotherapyColonColorectal cancerHumanKchip3Muc5acMucinsMucusNa+/ca2+ exchangeSn-6

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal eLife due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 7/92, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-03:

  • WoS: 8
  • Europe PMC: 8
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 35.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 33 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 112.
  • The number of mentions on the social network X (formerly Twitter): 13 (Altmetric).
  • The number of mentions in news outlets: 14 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (CANTERO RECASENS, GERARD) .

the authors responsible for correspondence tasks have been CANTERO RECASENS, GERARD and Malhotra, Vivek.

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Awards linked to the item

We thank all members of the Malhotra and Espinosa Lab for valuable discussions. Fluorescence microscopy was performed at the Advanced Light Microscopy Unit at the CRG, Barcelona. VM is an Institucio Catalana de Recerca i Estudis Avancats professor at the Centre for Genomic Regulation. This work was funded by grants from the Spanish Ministry of Economy and Competitiveness (BFU2013-44188-P to VM) and FEDER Funds, and Instituto de Salud Carlos III (PI19-00013 to LE). We acknowledge support of the Spanish Ministry of Economy and Competitiveness, through the Programmes 'Centro de Excelencia Severo Ochoa 2013-2017' (SEV-2012-0208 and SEV-2013-0347) and Maria de Maeztu Units of Excellence in R&D (MDM-2015-0502). This work reflects only the authors' views, and the EU Community is not liable for any use that may be made of the information contained therein.
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