{rfName}
Sp

Indexed in

License and use

Icono OpenAccess

Altmetrics

Analysis of institutional authors

Campelo, FelixAuthorMalhotra VAuthorVan Galen JAuthor

Share

February 21, 2020
Publications
>
Article

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network

Publicated to:Embo Journal. 36 (12): 1736-1754 - 2017-06-14 36(12), DOI: 10.15252/embj.201696048

Authors: Capasso, S; Luini, A; D'Angelo, G; Sticco, L; Rizzo, R; Pirozzi, M; Russo, D; Dathan, NA; Turacchio, G; Parashuraman, S; Campelo, F; van Galen, J; Malhotra, V; Hölttä-Vuori, M; Ikonen, E; Hausser, A; Riezman, I; Riezman, H; Luberto, C

Affiliations

Barcelona Inst Sci & Technol, Ctr Genom Regulat, Barcelona, Spain - Author
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Foton, Barcelona, Spain - Author
Barcelona Institute of Science and Technology (BIST) - Author
CNR, Inst Prot Biochem, Naples, Italy - Author
Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain - Author
Institució Catalana de Recerca i Estudis Avançats - Author
IRCCS Fondazione SDN - Author
Ist Ricovero Cura & Carattere Sci SDN, Naples, Italy - Author
Istituto Di Biochimica Delle Proteine, Naples - Author
Stony Brook University - Author
SUNY Stony Brook, Hlth Sci Ctr, Stony Brook Canc Ctr, Stony Brook, NY USA - Author
Univ Geneva, Dept Biochem, NCCR Chem Biol, Geneva, Switzerland - Author
Univ Helsinki, Fac Med, Minerva Res Inst Med Res, Dept Anat, Helsinki, Finland - Author
Univ Pompeu Fabra, Barcelona, Spain - Author
Univ Stuttgart, Inst Cell Biol & Immunol, Stuttgart, Germany - Author
Universitat Pompeu Fabra Barcelona - Author
Universitat Stuttgart - Author
UNIVERSITE DE GENEVE - Author
University of Helsinki Faculty of Medicine - Author
See more

Abstract

© 2017 The Authors Sphingolipids are membrane lipids globally required for eukaryotic life. The sphingolipid content varies among endomembranes with pre- and post-Golgi compartments being poor and rich in sphingolipids, respectively. Due to this different sphingolipid content, pre- and post-Golgi membranes serve different cellular functions. The basis for maintaining distinct subcellular sphingolipid levels in the presence of membrane trafficking and metabolic fluxes is only partially understood. Here, we describe a homeostatic regulatory circuit that controls sphingolipid levels at the trans-Golgi network (TGN). Specifically, we show that sphingomyelin production at the TGN triggers a signalling pathway leading to PtdIns(4)P dephosphorylation. Since PtdIns(4)P is required for cholesterol and sphingolipid transport to the trans-Golgi network, PtdIns(4)P consumption interrupts this transport in response to excessive sphingomyelin production. Based on this evidence, we envisage a model where this homeostatic circuit maintains a constant lipid composition in the trans-Golgi network and post-Golgi compartments, thus counteracting fluctuations in the sphingolipid biosynthetic flow.

Keywords

ceramidelipid territorieslipid?transfer proteinlipid‐transfer proteinptdins(4)pCeramideD-mediated phosphorylationEndoplasmic-reticulumHomeostasisLipid territoriesLipid-transfer proteinLipid-transfer proteinsMembrane contact sitesPhosphatidylinositol 4-phosphatePlasma-membranePleckstrin homology domainsProtein-kinase-dPtdins(4)pSphingomyelin synthases

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Embo Journal due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position 13/293, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.67. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 8.09 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 60
  • Scopus: 41
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 103.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 108 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.5.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Finland; Germany; Italy; Switzerland; United States of America.